Dichloro(methyl) silyl-substituted cyclopentadienyl titanium complexes

The synthesis of (C5H4)(SiMeCl2)(SiMe3) is described. The reaction of a dichloromethane solution of this compound with one equivalent of titanium tetrachloride leads to the monocyclopentadienyl complex [TiCl3{η5-C5H4(SiMeCl2)}]. Treatment of this complex with the lithium amides LiN(SiMe3)2 and LiNHtBu affords [TiCl2{N(SiMe3)2}{η5-C5H4(SiMeCl2)}] and [TiCl2{η5-C5H4[SiMeCl(η-NtBu)]}], respectively. Alkylation of the trichlorotitanium derivative with 1.5 equivalents of Mg(CH2C6H5)2(THF)2 leads to the tribenzyl derivative [Ti(CH2C6H5)3{η5-C5H4(SiMeCl2)}]. Hydrolysis of the trichloro- and tribenzyl-complexes leads to the μ-oxo dititanium compounds [TiX2μ-{η5-C5H4(η-OSiMeCl)}]2 (X=Cl, CH2Ph). All of the new complexes were characterized by elemental analysis and NMR spectroscopy.We are grateful to the DGICYT (Project PB-92-0178-C) and CAM (I + D 0034/94) for financial support.\ud B.R. acknowledges Universidad de Alcalá de Henares for support provided (Project 042/95

Hey children! Do you feel listened by your politicians? Evaluating a participative democratic programme

The objective of this study was to evaluate a participative democracy programme called Ágora infantil, carried out with students between the ages of 10 and 12. As in participatory budgets, the process is based on the research-action model (Lewin, 1946) and consists of the city council opening up decision-making on a part of the municipal budget or a concrete policy to the children of the municipality. This process of diagnosis, prioritization and decision-making was completed over the course of 5 to 7 sessions during school hours and implemented by the Coglobal association. Once the participants make a decision, the city council carries out the project selected in the municipality (the decision made is binding). The main goal of Ágora Infantil is to generate psychological empowerment and wellbeing amongst its participants, and to measure the effects of this programme on children’s psychological empowerment. To this end, we used Zimmerman´s model (Zimmerman, 1995; Zimmerman, 2000). The operationalization of the strengthening was based on: 1) knowledge of local politics (as a component of the interactional dimension of psychological empowerment) and 2) the self-perception of being able to influence the future of the municipality (component of the intrapersonal dimension of psychological empowerment). In addition, wellbeing was evaluated through the perception of being heard (Casas y Bello, 2012) and trust in the city council.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Empowering children in politics: evaluating a participative democratic programme

The objective of this study was to evaluate a participative democracy programme called Ágora infantil, carried out with students between the ages of 10 and 12. As in participatory budgets, the process is based on the research-action model (Lewin, 1946) and consists of the city council opening up decision-making on a part of the municipal budget or a concrete policy to the children of the municipality. This process of diagnosis, prioritization and decision-making was completed over the course of 5 to 7 sessions during school hours and implemented by the Coglobal association. Once the participants make a decision, the city council carries out the project selected in the municipality (the decision made is binding). The main goal of Ágora Infantil is to generate psychological empowerment and wellbeing amongst its participants, and to measure the effects of this programme on children’s psychological empowerment. To this end, we used Zimmerman´s model (Zimmerman, 1995; Zimmerman, 2000). The operationalization of the strengthening was based on: 1) knowledge of local politics (as a component of the interactional dimension of psychological empowerment) and 2) the self-perception of being able to influence the future of the municipality (component of the intrapersonal dimension of psychological empowerment). In addition, wellbeing was evaluated through the perception of being heard (Casas y Bello, 2012) and trust in the city council.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance

The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli strains that have different fosfomycin MICs. Our methods included the use of a hollow fiber infection model with three clinical ESBL-producing E. coli strains. Human fosfomycin pharmacokinetic profiles were simulated over 4 days. Preliminary studies conducted to determine the dose ranges, including the dose ranges that suppressed the development of drug-resistant mutants, were conducted with regimens from 12 g/day to 36 g/day. The combination of fosfomycin at 4 g every 8 h (q8h) and meropenem at 1 g/q8h was selected for further assessment. The total bacterial population and the resistant subpopulations were determined. No efficacy was observed against the Ec42444 strain (fosfomycin MIC, 64 mg/liter) at doses of 12, 24, or 36 g/day. All dosages induced at least initial bacterial killing against Ec46 (fosfomycin MIC, 1 mg/liter). High-level drug-resistant mutants appeared in this strain in response to 12, 15, and 18 g/day. In the study arms that included 24 g/day, once or in a divided dose, a complete extinction of the bacterial inoculum was observed. The combination of meropenem with fosfomycin was synergistic for bacterial killing and also suppressed all fosfomycinresistant clones of Ec2974 (fosfomycin MIC, 1 mg/liter). We conclude that fosfomycin susceptibility breakpoints (≤64 mg/liter according to CLSI [for E. coli urinary tract infections only]) should be revised for the treatment of serious systemic infections. Fosfomycin can be used to treat infections caused by organisms that demonstrate lower MICs and lower bacterial densities, although relatively high daily dosages (i.e., 24 g/day) are required to prevent the emergence of bacterial resistance. The ratio of the area under the concentration-time curve for the free, unbound fraction of fosfomycin versus the MIC (fAUC/MIC) appears to be the dynamically linked index of suppression of bacterial resistance. Fosfomycin with meropenem can act synergistically against E. coli strains in preventing the emergence of fosfomycin resistance.Consejería de Igualdad, Salud y Políticas Sociales Junta de Andalucía PI-0044-2013FEDER REIPI RD12/001

Role of Eu2+ and Dy3+ Concentration in the Persistent Luminescence of Sr2MgSi2O7 Glass-Ceramics

In this study, glass-ceramics based on Sr2MgSi2O7 phosphor co-doped with Eu/Dy were obtained from the sintering and crystallisation of glass powders. The glasses were melted in a gas furnace to simulate an industrial process, and the dopant concentration was varied to optimise the luminescence persistence times. The doped parent glasses showed red emission under UV light excitation due to the doping of Eu3+ ions, while the corresponding glass-ceramics showed persistent blue emission corresponding to the presence of Eu2+ in the crystalline environment. The dopant concentration had a strong impact on the sintering/crystallisation kinetics affecting the final glass-ceramic microstructure. The microstructures and morphology of the crystals responsible for the blue emission were observed by scanning electron microscopy–cathodoluminescence. The composition of the crystallised phases and the distribution of rare-earth (RE) ions in the crystals and in the residual glassy phase were determined by X-ray diffraction and energy dispersive X-ray analysis. The emission and persistence of phosphorescence were studied by photoluminescence.This research was funded by MICINN under projects PID2020-115419GB-C-21/C-22/AEI/ 10.13039/501100011033 and PID2019-107439GB-I00 and by the project PIE-CSIC 201960E016. And The APC was funded by PID2020-115419GB-C-21/C-22/AEI/ 10.13039/501100011033

Structure and luminescent properties of Sm/Dy-doped Sr2MgSi2O7 glass-ceramics

Sm3+-doped and Sm3+/Dy3+ codoped SiO2–SrO–MgO glasses were prepared by conventional melt quenching and Sr2MgSi2O7 based glass–ceramics from sintering and crystallization of the glass powders. The thermal, structural, and optical properties of the glasses and glass–ceramics were investigated as a function of the dopant concentration. The optical characterization includes the photoluminescence spectra and the lifetimes of the 4G5/2 (Sm3+) and 4F9/2 (Dy3+) excited states. In Sm3+ single-doped samples, the emission intensity increases up to a concentration of 0.3 mol% Sm3+ ions and then decreases due to nonradiative energy transfer processes. The emission spectra in the glass–ceramics show a more resolved structure and higher intensity compared to the glass samples, suggesting a different and crystalline environment for the Sm3+ ions. The non-radiative processes also influence the experimental decays of the glass samples which deviate from a single exponential with lifetimes decreasing as Sm3+ concentration increases. The emission and excitation spectra of the codoped samples do not show significant energy transfer between Sm3+ and Dy3+ ions. Different emitting colors can be obtained in the codoped glasses by changing the excitation wavelength. The studied glass–ceramics could be applied as enamels on ceramic or metallic substrates.Funding from MICINN under projects PID2020-115419GB-C-21/C-22/AEI/ 10.13039/501100011033, PID2019-107439GB-I00 and PIE-CSIC 201960E016 is acknowledged

Real space manifestations of coherent screening in atomic scale Kondo lattices

The interaction among magnetic moments screened by conduction electrons drives quantum phase transitions between magnetically ordered and heavy-fermion ground states. Here, starting from isolated magnetic impurities in the Kondo regime, we investigate the formation of the finite size analogue of a heavy Fermi liquid. We build regularly-spaced chains of Co adatoms on a metallic surface by atomic manipulation. Scanning tunneling spectroscopy is used to obtain maps of the Kondo resonance intensity with sub-atomic resolution. For sufficiently small interatomic separation, the spatial distribution of Kondo screening does not coincide with the position of the adatoms. It also develops enhancements at both edges of the chains. Since we can rule out any other interaction between Kondo impurities, this is explained in terms of the indirect hybridization of the Kondo orbitals mediated by a coherent electron gas, the mechanism that causes the emergence of heavy quasiparticles in the thermodynamic limit.Financial support was provided by the Spanish Plan Nacional de I+ D+ i (grants MAT 2013-46593-C6-3-P, MAT2016-78293-C6-6-R, MAT2015-66888-C3-2-R, and FIS2015-64886-C5-3-P), Charles University (programme PRIMUS/Sci/09) and the European Union through programmes Interreg-POCTEFA (grant TNSI/EFA194/16) and H2020-EINFRA-5-2015 MaX Center of Excellence (grant no. 676598). M. M.-L., M. P., and D. S. acknowledge the use of SAI at Universidad de Zaragoza. R. R. acknowledges The Severo Ochoa Centers of Excellence Program (grant no. SEV-2017-0706) and Generalitat de Catalunya (grant no. 2017SGR1506 and the CERCA Programme)

Acute Effects of Global Postural Re-Education on Non-Specific Low Back Pain. Does Time-of-Day Play a Role?.

Low back pain is one the most common forms of musculoskeletal disorders. Thus, several physiotherapeutic strategies (e.g., global postural re-education therapy) have been used for reducing low back pain. The aim of this study was to determinate if acute application of global postural re-education session associated effects are influenced by the time-of-day when this physical therapy is applied. Eight participants in a randomized, counterbalanced order were acutely tested both before and 24 h after a global postural re-education therapy session (10 min session) in three different time-of-day points; morning (i.e., AM; 7:00–9:00 h), midday (i.e., AM; 12:00–14:00 h) and afternoon (i.e., PM; 18:00–20:00 h). In each session, low back pain Visual Analogue Pain Scale [VAS]), flexibility, function capacity (Roland Morris Questionnaire [RMQ], and physical functioning Oswestry Disability Index [ODI]) were recorded. Results showed a pain reduction (VAS Scale) 24 h post Global postural re-education [GPR] session (p = 0.001) and increasing of flexibility pre-post GPR session in all the time-of-day points (morning, midday, and afternoon) (p = 0.001) while no differences were reported in RMQ (p = 0.969) and ODI (p = 0.767). Thus, acute GPR session produces the same effects on flexibility, low back pain, function capacity, and physical functioning values independently of time-of-day when it is applied.post-print974 K